AI × Synthetic Biology

Design biology like an engineer.

Cellora uses AI to design programmable cellular systems from desired biological behavior.

GENEPROMOTERSIGNALRECEPTORREGULATORPATHWAY
components
26
interactions
61
model_confidence
0.87
state
active
The translation layer

Biology is programmable. We are building the compiler.

Cellora takes a specification of desired biological behavior and returns candidate biological architectures — components, regulation and interactions — that could produce it.

Desired behavior
INPUT Ainput
LOW OXYGENinput
SIGNAL Binput
Desired state
ACTIVATE RESPONSE
Cellora
compile
Biological architecture
PROMOTER
REGULATOR
SIGNALING PATHWAY
TARGET GENE
CELLULAR RESPONSE

Cellora is not analyzing biology after the fact. It is proposing the architecture before the experiment exists.

Design cycle

Start with behavior. Work backward to biology.

The loop does not end at a prediction. Every experiment re-enters the model as constraint.

010203040506CYCLEDEFINE
  1. step 01
    DEFINE

    Desired cellular behavior.

  2. step 02
    DESIGN

    Candidate genetic and signaling architecture.

  3. step 03
    SIMULATE

    Model system behavior under different conditions.

  4. step 04
    RANK

    Identify the most promising designs.

  5. step 05
    TEST

    Experimental validation.

  6. step 06
    LEARN

    Experimental results feed the next design cycle.

Systems, not entities

A biological system is more than a gene.

Change one component and the consequences propagate. Cellora models the interactions, not the parts in isolation.

ENVIRONMENTSIGNALRECEPTORPATHWAYREGULATORPROMOTERGENE
downstream propagation
PROMOTER ACTIVITYΔ 0.61
GENE EXPRESSIONΔ 0.48
CELL STATEΔ 0.35
SYSTEM RESPONSEΔ 0.22
Design space

Explore the design space before entering the lab.

Candidate architectures are generated, scored against biological constraints and clustered before any bench time is spent.

EFFICIENCYSTABILITY
candidate architectures
12,482
high-confidence candidates
147
experimental candidates
23
filters
constraint_checkpass
uncertainty0.14
simulationrunning
State space

Biology changes state. So does the model.

Cellular behavior is conditional. Cellora carries environmental context and uncertainty through every predicted transition.

temperature37°C
oxygen12%
nutrient8mM
signal44nM
Experimental feedback

Designs are hypotheses. Experiments make them real.

Observed biology disagrees with the model constantly. That disagreement is the training signal.

closed loop
  1. COMPUTATIONAL DESIGN01
  2. CANDIDATE SYSTEM02
  3. LAB EXPERIMENT03
  4. OBSERVED RESPONSE04
  5. MODEL UPDATE05
  6. NEXT DESIGN06
system_idexpectedobserveddelta
01CX-0428-A0.810.74-0.07
02CX-0431-C0.770.53-0.24
03CX-0439-E0.710.69-0.02
04CX-0428-B0.620.88+0.26
05CX-0433-D0.490.66+0.17
Application surface

One design engine. Many biological systems.

The same design loop applies wherever cellular behavior has to be specified, engineered and tested.

Cellora
biological
design engine
SYNTHETIC BIOLOGY01
  • programmable cellular systems
  • genetic circuits
BIOMANUFACTURING02
  • engineered production pathways
  • cellular optimization
BIOSENSORS03
  • cellular detection systems
  • signal-responsive biology
THERAPEUTICS RESEARCH04
  • cellular mechanisms
  • experimental hypothesis generation
DIAGNOSTICS RESEARCH05
  • biological response systems
  • signal interpretation
Conceptual design space

The design space is combinatorial.

A handful of biological components produces an intractable number of possible systems. Search has to happen computationally before it happens at the bench.

expansion
10
10 components
10²
10² interactions
10³
10³ configurations
10⁶+
10⁶+ candidate systems
Architecture

The laboratory becomes a feedback signal.

An AI-native biological R&D loop: design computationally, measure physically, and let the difference rewrite the model.

CELLORA MODEL
Generative Design
System Simulation
Architecture Ranking
Uncertainty Estimation
EXPERIMENTAL LAYER
Cellular assay
Phenotypic measurement
Molecular readout
Environmental response
LEARNING LOOP
Observed ≠ Predicted
Model update
Cellora

Living systems are programmable.

An AI design engine for living systems.

designsimulatetestlearn
Cellora logoCelloraEngineering biology with AI — seed stagehello@cellora-labs.com